Scientists have found that proteins can be removed from the brain’s fear center to delete memories forever. The research has drawn interest — and concern — from some involved in mental healthcare.
Reporting from Baltimore —
Soldiers haunted by scenes of war and victims scarred by violence may wish they could wipe the memories from their minds. Researchers at Johns Hopkins University say that may someday be possible.
A commercial drug remains far off — and its use would be subject to many ethical and practical questions. But scientists have laid a foundation with their discovery that proteins can be removed from the brain’s fear center to erase memories forever.
“When a traumatic event occurs, it creates a fearful memory that can last a lifetime and have a debilitating effect on a person’s life,” said Richard L. Huganir, professor and chair of neuroscience in the Johns Hopkins School of Medicine. He said his finding on the molecular process “raises the possibility of manipulating those mechanisms with drugs to enhance behavioral therapy for such conditions as post-traumatic stress disorder.”
The research has drawn interest — and concern — from some involved in mental healthcare.
Kate Farinholt, executive director of the mental health support and information group National Alliance on Mental Illness of Maryland, said many people suffering from a traumatic event might benefit from erasing a memory. But there are a lot of unanswered questions, she said.
“Erasing a memory and then everything bad built on that is an amazing idea, and I can see all sorts of potential,” she said. “But completely deleting a memory, assuming it’s one memory, is a little scary. How do you remove a memory without removing a whole part of someone’s life, and is it best to do that, considering that people grow and learn from their experiences?”
Research already had shown that a specific form of behavior therapy seemed to erase painful memories. But relapse was possible because the memory wasn’t necessarily gone.
By looking at that process, Huganir and postdoctoral fellow Roger L. Clem discovered a “window of vulnerability” when unique receptor proteins are created. The proteins mediate signals traveling within the brain as painful memories are made. Because the proteins are unstable, they can be easily removed with drugs or behavior therapy during the window, ensuring the memory is eliminated.
Researchers used mice to find the window, but think the process would be the same in humans. They used electric shocks to condition the rodents to fear a certain tone. The sound triggered creation of the proteins, called calcium-permeable AMPARS, which formed for a day or two in the fear center, or amygdala, of the mice’s brains.
The researchers are working on ways to reopen the window down the road by recalling the painful memory and using medication to eliminate the protein.
Huganir, whose report on erasing fear memories in rodents was published online last month by Science Express, also thinks that the window may exist in other centers of learning and may eventually be used to treat pain or drug addiction.
There are medications also targeting the amygdala and used with behavior therapy that can lessen the emotional response to painful memories, such as propranolol, a beta blocker commonly used to treat hypertension.
Paul Root Wolpe, director of the Center for Ethics at Emory University in Atlanta, said that permanently erasing memories in humans, if it could be done, wouldn’t be a lot different ethically than behavior modification.
He also said that PTSD sufferers, such as service members in Iraq and Afghanistan, frequently experienced more than one traumatic event, and trying to eliminate all the memories could significantly alter a person’s personality and history.
“I don’t know what it means to erase that much of a person’s life,” he said. “You’d leave a giant hole in a person’s history. I tend to doubt you’d even be able to.
“Certainly, there may be appropriate applications,” he said. “But human identity is tied into memory. It creates our distinctive personalities. It’s a troublesome idea to begin to be able to manipulate that, even if for the best of motives.”
Source: http://www.latimes.com/news/science/la-na-protein-memories-20101202,0,7759822.story